Best Pizza in South Carolina: Our 9 Favorites!

Thin and crispy or deep dish, extra cheesy or extra saucy, meat lover’s dream or veggie delight—no matter how you slice it, there are about as many ways to make a pizza as there are people who enjoy eating it. These 9 pizza places in South Carolina are serving up some of the best pizza you can get this side of the Atlantic. 

Peppino’s Pizzeria, Clemson, SC

Two words: Pizza. Heaven. Peppino’s started out fueling the appetites of hungry Clemson students and residents, but word traveled fast and they soon had to expand to three locations in the Upstate. Go grab a slice, and you’ll see why.

Serafino’s, Myrtle Beach, SC

You probably won’t find this place unless you’re a local or you’re looking for it. Tucked well away from the bustling thoroughfares of the Grand Strand, Serafino’s is the go-to source for pizza and other delicious cuisine.

Joe’s New York Pizza, Seneca, SC

Whoever Joe is, he sure knows how to make an awesome pizza! They’ve got all the classic pizzeria offerings, from wings and breadsticks to subs and salads. But if you want to spice up the traditional pizza pie, swap out the ol’ mozz for ghost pepper cheese, or add some green chiles for some smokin’ hot flavor. And the garlic knots are “knot” to be missed!

Chicago Pizza, Surfside Beach, SC

Skip the Windy City, and opt for some sand, surf, and Chicago-style pizza at one of Surfside Beach’s most beloved eateries. The Chicago pizza scene features nearly every spice of life, which is exactly what you’ll find here. Even Chicagoans can’t tell the difference!

Mig’s Pizza Castle, Greenwood, SC

The only thing that can make Mig’s Pizza Castle even more amazing would be if they were serving up their delicious pizza in a real castle. The only thing you’ll be wondering is if you should order extra for leftovers or just come back the next day.

Venus Pie Pizzeria, Spartanburg, SC

While most pizza restaurants have branched out into wings, subs, and other menu offerings, Venus Pie Pizzeria sticks to what they do best. Serving up made-from-scratch pizza by the slice and by the pie, calzones, and breadsticks, Venus Pie has attracted a strong local following for a reason—it’s simply the best around.

Andolini’s Pizza, Charleston, SC

This authentic New York-style pizza has set up shop in the Lowcountry, proving that some of the south’s best cuisine doesn’t have to be deep fried or overly sweet. Touted as some of the best pizza in the area, you’ll wonder how you ever got through life without it.

Dano’s Pizza, Columbia, SC

Usually, you’d have to travel to New York to get pizza this good. But this delicious gem has been serving up authentic New York slices for over 13 years right in the heart of palmetto state. Even born and bred New Yorkers will admit a pizza from Dano’s makes them reminiscent of their northern cuisine.

Piace Pizza, Beaufort, SC

No worries if you can’t pronounce it-you’ll be too busy savoring their cheesy goodness to care. This award-winning, two location pizza palace is king of the local pizza population, serving up crispy crusty slices, whole pies, and stromboli.

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